Levin has been investigating the molecular mechanisms involved in retrovirus replication. Marshall Nirenberg, where she performed studies on protein synthesis and the genetic code. She has spent her entire professional career at the NIH, coming initially to work as a postdoctoral fellow in the laboratory of Dr. degree in Biochemistry from Columbia University. degree in Biochemistry from Harvard University, and a Ph.D. degree in Chemistry from Barnard College, an M.A. Levin is currently Head, Section on Viral Gene Regulation in the Program on Genomics of Differentiation, NICHD. In other studies, our efforts are directed toward understanding the function of the viral capsid protein (CA) in HIV-1 assembly and early postentry events during the course of virus replication in vivo.ĭr. We are also investigating the mechanism of antiviral activity of two human cytidine deaminases, APOBEC3G (A3G) and APOBEC3A (A3A). Much of our work focuses on the viral nucleocapsid protein (NC), a nucleic acid chaperone that remodels nucleic acid structures so that the most thermodynamically stable conformations are formed-an activity that is critical for highly efficient and specific viral DNA synthesis. To investigate the individual steps in HIV-1 reverse transcription, a major target of HIV therapy, we have developed reconstituted model systems. These studies are critical for developing new strategies to combat the AIDS epidemic, which continues to be a global threat to human health. The goal of the research performed in the Section on Viral Gene Regulation is to define the molecular mechanisms responsible for the replication of HIV and related retroviruses and to investigate the role of host proteins that block virus infection.

OL5842216W Page_number_confidence 85.16 Pages 130 Partner Innodata Pdf_module_version 0.0.20 Ppi 300 Rcs_key 24143 Republisher_date 20201116184315 Republisher_operator Republisher_time 246 Scandate 20201113233049 Scanner Scanningcenter cebu Scribe3_search_catalog isbn Scribe3_search_id 9780791096031 Tts_version 4.Molecular Genetics of Mammalian Retrovirus Replication Access-restricted-item true Addeddate 10:44:26 Boxid IA1998114 Camera Sony Alpha-A6300 (Control) Collection_set printdisabled External-identifier

حمورابی by Judith Levin